LT β R in Ly 49 and NKG 2 acquisition
نویسندگان
چکیده
This work was supported by grants from the Fund for Scientific Research-Flanders (Belgium), the Research-fund of Ghent University and the Belgian Federation against Cancer, non profit organisation. F. S. is a Ph.D. student and K. V. B. is a post-doc., both supported by the Research-fund of Ghent University. V. D. C. and A. S. F. are research assistants of the Fund for Scientific Research-Flanders.
منابع مشابه
Positive and negative roles of the trans-acting T cell factor-1 for the acquisition of distinct Ly-49 MHC class I receptors by NK cells.
Members of the Ly-49 gene family code for class I MHC-specific receptors that regulate NK cell function. Due to a combinatorial distribution of Ly-49 receptors, NK cells display considerable clonal heterogeneity. The acquisition of one Ly-49 receptor, Ly-49A is strictly dependent on the transcriptional trans-acting factor T cell-specific factor-1 (TCF-1). Indeed, TCF-1 binds to two sites in the...
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